Bridging autoinflammatory and autoimmune diseases

نویسندگان

چکیده

Abstract Background Autoimmunity is used to cause by impairment of adaptive immunity alone, whereas autoinflammatory was originally defined as a consequence unregulated innate immunity. So, the pathogenetic mechanisms autoimmune diseases were well-thought-out be mediated B and T lymphocytes. Whereas, unprovoked times inflammation with absence high titre autoantibodies. Main body abstract Autoimmune split into two groups, but considering similarities, it can considered only one group large immune pathological clinical spectrum which involves at end pure other . Conclusions We safely conclude that there bridging between diseases.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases

Osteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammatory diseases. In some cases, the mechanisms of these effects have been described, but many aspects...

متن کامل

Behçet’s Disease: Autoimmune or Autoinflammatory?

Behçet's disease (BD) is a systemic inflammatory disease characterized by recurrent oral aphthae, genital ulcers, ocular inflammation and skin lesions. Involvement of large vessels, central nervous system, and gastrointestinal tract, and thrombotic events are less frequent but can be life threatening. Ocular complications of BD are some of the most devastating for patients with a major impact o...

متن کامل

The autoinflammatory diseases.

The monogenic autoinflammatory syndromes are conditions caused by mutations of genes coding for proteins that play a pivotal role in the regulation of the inflammatory response. Due to their genetic nature, most of these disorders have an early onset. Clinically they are characterised by recurrent flares of systemic inflammation presenting most of the time as sudden fever episodes associated ...

متن کامل

[Hereditary systemic autoinflammatory diseases].

Systemic autoinflammatory diseases encompass different rare clinical entities characterized by recurrent acute inflammatory episodes secondary to a dysregulated inflammatory process. Since their first clinical descriptions, the Mendelian hereditary nature of some of them became evident, with their genetic and molecular basis being recently elucidated. There are disease-causing mutations in gene...

متن کامل

Autoinflammatory diseases in pediatrics.

Autoinflammatory diseases (AIDs) are characterized by recurrent episodes of systemic and organ-specific inflammation. Many of these diseases share fever as a common presenting feature. Physicians need to consider AIDs in children with recurrent, unexplained fevers, when infectious and malignant causes have been discarded. This article discusses the differential diagnosis of recurrent fever in c...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The Egyptian Journal of Internal Medicine

سال: 2021

ISSN: ['1110-7782', '2090-9098']

DOI: https://doi.org/10.1186/s43162-021-00040-5